We discuss a fresh approach outlined by the US Department of Energy, known as Cyber Informed Engineering (CIE). It’s an approach that focuses on impenetrable safety measures, manual controls, and robust engineering safeguards that are added to the existing and conventional cybersecurity methods. In this particularly significant 100th episode of the Industrial Security Podcast, we are joined by Cheri Caddy, the Deputy Assistant Cyber Director of the United States, to delve into the initiative to establish a novel engineering discipline. This discipline emphasizes the essential role of engineering principles, tools, and methods, alongside the customary IT security techniques.